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Journal of the Korean Child Neurology Society 2005;13(1):1-7.
Published online May 30, 2005.
Epilepsy, Reactive Oxygen Species and Mitochondria.
Won Seop Kim
Department of Pediatrics, College of Medicine, Chungbuk National Universty, Cheongju, Korea.
Abstract
Epilepsy is a neurological disorder from many molecular and biochemical responses. In the underlying mechanism, reactive oxygen species play an important role in seizure initiation and seizure-induced brain damage. In mitochondrial diseases, epileptic seizures are also noted from defects of oxidative phosphorylation. So oxidative stress from reactive oxygen species is important in mitochondrial dysfunction and epileptic seizure.
Key Words: Epilepsy, Reactive oxygen species, Mitochondria
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