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Journal of the Korean Child Neurology Society 2005;13(2):195-201.
Published online November 30, 2005.
Genetic Propensity to Neuroinflammatory CNS Diseases in Korean Children: Molecular Typing of HLA Class II.
Woo Saeng Park, Jun Hwa Lee, Hee Du Jung, Hyun Hee Oh, Soon Hak Kwon
1Department of Pediatrics, College of Medicine, Ulsan University, Korea.
2Department of Pediatrics, Catholic University of Daegu School of Medicine, Korea.
3Department of Laboratory Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
4Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. shkwon@knu.ac.kr
Abstract
PURPOSE
The study was aimed to investigate immunogenetic peculiarities of neuroinflammatory CNS diseases in Korean children. METHODS: A total of 16 children with neuroinflammatory CNS diseases(9 males and 7 females; mean age 7.5+/-4.2 years) were consecutively recruited. Genomic typings were performed on their HLA DRB/HLA DQB genes using PCR-SSOP/SSP techniques with Gel immunoelectrophoresis. RESULTS: The frequencies of HLA-DRB1*14(38%), HLA-DRB1*15(25%), HLA-DRB3* 02(50%), HLA-DQB1*05(56%) and DQB1*06(44%) were significantly increased compared with a control group. The frequencies of HLA-DRB1*15(50%) and HLA-DQB1*06(63%) were significantly increased in children with ADEM and HLA-DRB3*0202(100%), HLA- DRB1*1302(67%), HLA-DRB3*0301(67%), and HLA-DQB1*0301(67%) in children with multiple sclerosis. HLA-DRB1*1401, HLA-DRB3*0202, and HLA-DQB1*0502 were found in children with acute necrotizing encephalopathy. CONCLUSION:HLA-DRB1*14, HLA-DRB1*15, HLA-DRB3*02, HLA-DQB1*05 and DQB1*06 may be associated with the susceptibility to neuroinflammatory CNS diseases in Korean children. The frequencies of HLA-DRB1*1501, HLA-DRB5*0101, HLA-DRB3* 0301, and HLA-DQB1*0602 in Korean children with multiple sclerosis were not as high as those in western children. However, HLA-DRB3*0202 was seen in all the children with multiple sclerosis. Our data may provide further evidence that the immunogenetic backgrounds of neuroinflammatory CNS diseases in Korean children are distinctly different from those in Westerns. However, further studies are needed.
Key Words: Neuroinflammatory diseases, HLA-DRB, HLA-DQB, Acute disseminated encephalomyelitis, Multiple sclerosis, Acute necrotizing encephalopathy
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