A Case of Acute Isoniazid Intoxication in Childhood.

Kook,  Dong Hyuk; Cho,  Sun Young; Lee,  Kyung Yil; Lee,  In Goo; Lee,  Joon Sung

Case Report

Journal of the Korean Child Neurology Society 2006;14(2):358-362.
Published online November 30, 2006.

A Case of Acute Isoniazid Intoxication in Childhood.

Dong Hyuk Kook, Sun Young Cho, Kyung Yil Lee, In Goo Lee, Joon Sung Lee

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. leekyungyil@catholic.ac.kr

Abstract

Acute isoniazid overdose is a relatively uncommon but potentially life-threatening event. Isoniazid overdose should be suspected in any patient with repeated seizures, coma and metabolic acidosis of uncertain etiology. The effective antidote for acute isoniazid- induced neurotoxicity is known to be pyridoxine. We report a 4-month old boy who showed repeated seizures, coma, metabolic acidosis and hyperglycemia from an accidental isoniazid overdose(100 mg/kg). This boy was recovered completely by the pyridoxine treatment with a dose of equivalent to the amount of isoniazid ingested.

Key Words: Isoniazid, Intoxication, Child