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Journal of the Korean Child Neurology Society 2007;15(1):67-74.
Published online May 30, 2007.
Prognostic Factors of Developmental Delay in Premature Infants.
Joon Won Kang, Keon Su Lee
Department of Pediatrics, College of Medicine, Chungnam National University, Daejeon, Korea. ksulee@cnu.ac.kr
With advancement of neonatal intensive care since 1960's, the survival of prematurities and low birth weights has been improved. However, there is a high risk of poor growth, neurodevelopmental delay, deafness, and blindness. This study was aimed to the relationship of perinatal risk factors and neonatal complications with Bayley Scales of Infant Development II(BSID-II) scores in premature infants. METHODS: 127 infants admitted between January 2001 and December 2005, were studied at their mean corrected age of 12.1 months. Perinatal risk factors, neonatal complications and developmental outcomes were evaluated. The subjects were grouped by BSID-II scores: 42 infants with normal development[Mental Developmental Index(MDI) and Psychomotor Developmental Index(PDI)> or=85] in Group 1, and 85 with poor or abnormal outcomes(MDI or PDI<85) in Group 2. RESULTS: MDI and PDI in Groups 1 and 2 were 95.1+/-8.8 and 99.2+/-11.2 vs. 69.7+/-14.9 and 68.1+/-14.1, respectively. There were significant differences in gestational age, Apgar score at 5 minute, pH on ABGA at birth, and peak bilirubin levels between two groups. CONCLUSION: Gestational age, Apgar score at 5 minute, pH on ABGA at birth, and peak bilirubin levels would be risk factors for developmental delay in premature infants. However, further studies are needed.
Key Words: Risk factors, Developmental delay, Prematurity


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