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Journal of the Korean Child Neurology Society 2007;15(2):211-215.
Published online November 30, 2007.
A Case of Child with Miller Fisher Syndrome Diagnosed by Anti-GQ1b Antibody from Mycoplasma Pneumoniae.
Heewon Chueh, Eun Young Kwon, Hye Young Shin, Kyu Geun Hwang
Department of Pediatrics, College of Medicine, Dong-a University, Busan, Korea. kghyang@dau.ac.kr
Miller Fisher syndrome, first reported by Miller Fisher in 1956, is characterized by a triad of external ophthalmoplegia, areflexia, and ataxia. Many features shared with Guillain-Barre syndrome; CSF usually shows elevated proteins and the syndrome is often is preceded by an infectious disorder. It is believed that the level of anti-GQ1b IgG antibody is elevated during an acute phase, increases and decreases rapidly during clinical recovery, that the level of anti-GQ1b IgG can be used as a diagnostic tool for Miller Fisher syndrome during an acute phase. We report an 8 year-old boy who showed typical clinical manifestations of Miller Fisher syndrome, with respiratory tract illness, associated with the seroconversion of Mycoplasma pneumoniae titers during the development of neurological symptom, with positive anti- GQ1b IgG.
Key Words: Miller Fisher syndrome, Anti-GQ1b antibody, Mycoplasma pneumoniae pneumonia
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