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Journal of the Korean Child Neurology Society 2009;17(1):1-9.
Published online May 30, 2009.
Brain Inflammation and Epilepsy in Experimental Animals.
Young Se Kwon
Department of Pediatrics, Inha University Hospital, Incheon, Korea. ysped@inha.ac.kr
Abstract
In epilepsy, there have been increasing experimental reports on the interaction between seizures and inflammation. Proinflammatory cytokines such as interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 are rapidly increased after seizure was induced in experimental rodents. Preexisting inflammation enhances vulnerability of hippocampal neurons to status epilepticus, resulting in neuronal injury in the developing brain. Although too little is known about the role of inflammation in brain with seizures, actions of anti-inflammatory drugs, and how neuroprotection would be produced, increasing evidence has been presented that multiple mechanisms may underlie neuronal injury following inflammation-exacerbated status epilepticus. In this article will be reviewed the experimental studies for the role of brain inflammation in epilepsy.
Key Words: Epilepsy, Inflammation, Antiinflammatory drug
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