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Journal of the Korean Child Neurology Society 2010;18(1):33-39.
Published online May 30, 2010.
Risk Factors of Epilepsy after Central Nervous System Infection in Children.
Mee Young Baek, Young Mi Kim, Yun Jin Lee, Sang Ook Nam
Department of Pediatrics, College of Medicine, Pusan National University, Yangsan, Korea. wearehan@yahoo.co.kr
We performed this study in order to investigate the incidence and risk factors in acute phase of epilepsy after previous central nervous system (CNS) infection. METHODS: We retrospectively studied 74 children with epilepsy after CNS infection from January 2000 to June 2007. We compared the significant difference of the demographic findings, underlying disease, clinical features, and findings of EEG and brain MRI between the epilepsy group and the control group after CNS infection. RESULTS: Overall incidence of patients with epilepsy after CNS infection was 12.2%. The incidence of epilepsy in the children with seizure during acute stage of the illness, vomiting, decreased mentality, fever and headache was 26.5%, 24.0%, 16.6%, 10.2%, 9.1%, respectively. The incidence of epilepsy in children who had abnormal findings of EEG and brain MRI was 28.5% and 20.0%. The children who had seizure during acute stage(P=0.0005), vomiting(P=0.0261) and abnormal EEG finding(P=0.0065) had significantly higher incidence of epilepsy after CNS infection. CONCLUSION: The incidence of children with epilepsy after CNS infection was 12.2%. Special attention and follow-ups are needed to detect vomiting, seizure and abnormal EEG findings in acute phase of CNS infection.
Key Words: Central nervous system infections, Epilepsy, Risk factors, Incidence


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