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Journal of the Korean Child Neurology Society 2002;10(2):369-373.
Published online November 30, 2002.
Two Cases of Familial Hypokalemic Periodic Paralysis Caused by Salty Foods.
Hyun Ji Kim, So Young Lee, Mi Young Kim, Na Yun Kim, Sun Ju Lee, Won Duck Kim, Sung Min Jo, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Department of Pediatrics, College of Medicine, Dongguk University, Kyongju, Korea. khjwood@hanmail.net
Hypokalemic periodic paralysis is an autosomal dominant disorder characterized by episodic weakness of skeletal muscle associated with hypokalemia. It may be presented as familial or sporadic. Familial hypokalemic periodic paralysis is caused by mutations in the muscle membrane dihydropyridine sensitive calcium channel alpha-1 subunit. The abnormal genes in most cases are located in the chromosome 1q31-32. We experienced 2 cases(a 14-year-old male, a 12-year old male) of familial hypokalemic periodic paralysis. Two cases presented with quadriplegia after eating salty foods. The diagnosis was made by demonstrating decreased plasma level of potassium. The patient responded dramatically to potassium replacement therapy. We report two cases of familial hypokalemic periodic paralysis caused by salty foods with a brief review of related literatures.
Key Words: Hypokalemia, Familial, Periodic paralysis, Salty foods
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