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Journal of the Korean Child Neurology Society 2003;11(1):20-23.
Published online May 30, 2003.
The Protective Effect of Chlorpromazine on Pentylenetetrazole Induced Seizure.
Eun Ah Kim, Dong Wook Kim, Soo Ahn Chae
1Department of Pediatrics, College of Medicine, Inje University Seoul Paik Hospital, Seoul, Korea.
2Department of Pediatrics, College of Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea. dwkim@ilsanpaik.ac.kr
3Department of Pediatrics, College of Medicine, Chung-Ang University, Seoul, Korea.
Abstract
PURPOSE
Chlorpromazine(CPZ) is known to inhibit glutamate dehydrogenase(GDH). Reductive amination of alpha-ketoglutarate is catalyzed by GDH and forms glutamate, a major excitatory neurotransmitter. Thus, we hypothesized that CPZ might have a seizure-protective effect by inhibition of glutamate release from the excitatory presynaptic nerve terminal. The present study was designed to investigate the protective effect of CPZ on pentylenetetrazole(PTZ)-induced seizure in rats. METHODS: Twenty male Sprague-Dawley rats were equally divided into 2 groups. CPZ(20 mg/kg) was administered to experimental animals by subcutaneous injection, while normal saline to control animals. Twenty minutes later, seizures were chemically induced by intraperitoneal injection of PTZ(60 mg/kg). Seizure severity was evaluated by using a scoring system of seizure behaviors:0, no seizure; 0.5, abnormal behavior; 1, myoclonic jerk; 2, myoclonic jerk with jumping; 3, forelimb clonus with preserving righting reflex; 4, generalized clonic seizure with brief loss of righting reflex; 5, generalized tonic clonic seizure; 6, expire. A greater score represents a more severe seizure. RESULTS: The seizure behavior scores(2.8+/-0.2) in the experimental group were significantly lower than those(3.9+/-0.4) in the control group(P<0.05). CONCLUSION: This study demonstrates that CPZ decrease PTZ-induced seizure severity in rats. Our results suggest that CPZ may have a seizure-protective effect. We hope that further studies on this issue should be performed in near future.
Key Words: Chlorpromazine, Pentylenetetrazole, Seizure severity, Effect, Rat


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