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Journal of the Korean Child Neurology Society 2013;21(1):1-6.
Published online March 30, 2013.
Effectiveness and Tolerability of Fosphenytoin for Pediatric Status Epilepticus.
Won Gi Hong, Il Han Yoo, Jon Soo Kim, Hye Won Ryu, Sung Hwan Byun, Hunmin Kim, Byung Chan Lim, Jong Hee Chae, Jieun Choi, Ki Joong Kim, Yong Seung Hwang, Hee Hwang
1Pediatric Clinical Neuroscience Center, Department of Pediatrics, Seoul National University Children's hospital, Seoul, Republic of Korea.
2Department of Pediatrics, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea. neuroandy@snubh.org
3Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
4Department of Pediatrics, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
Abstract
PURPOSE
The study was aimed to investigate the effectiveness and tolerability of intravenous fosphenytoin (fPHT) in the treatment of pediatric status epilepticus (SE). METHODS: Medical-records of patients who received intravenous (IV) fPHT for the treatment of SE were retrospectively reviewed and their clinical data were analyzed regarding age, gender, seizure types, underlying neurologic status, use of other anticonvulsants, loading dose, response and adverse events of IV fPHT. RESULTS: Twenty patients (12 boys and 8 girls) were included in the study. The mean age at administration of IV fPHT was 3.98 years (range 0-18.6 years). Of the 20 patients, 15 patients had no underlying neurological conditions, but five patients were on anticonvulsants. IV fPHT terminated the seizures in 15 of the 20 patients (75%). No adverse events occurred during or after the infusions. CONCLUSION: This study demonstrated that IV fPHT was as effective as phenytoin and was well-tolerated in the treatment of pediatric SE. IV fPHT can be considered as a substitute for phenytoin in the management of pediatric SE.
Key Words: Fosphenytoin, Pediatric, Status Epilepticus, Effectiveness, Tolerability


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