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Ann Child Neurol > Volume 26(4); 2018 > Article
Journal of the Korean Child Neurology Society 2018;26(4):210-214.
DOI: https://doi.org/10.26815/jkcns.2018.26.4.210    Published online December 31, 2018.
Iron Deficiency Anemia: The Possible Risk Factor of Complex Febrile Seizure and Recurrence of Febrile Seizure
Chan Young Lee, Na Mi Lee, Dae Yong Yi, Sin Weon Yun, In Seok Lim, Soo Ahn Chae
Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea
Correspondence:  Soo Ahn Chae, Tel: +82-2-6299-1479, Fax: +82-2-6264-2167, 
Email: kidbrain@korea.com
Received: 24 August 2018   • Revised: 11 October 2018   • Accepted: 11 October 2018
A relationship between Febrile seizure (FS) and iron deficiency anemia (IDA) has been found in several studies. However, few studies have focused on the role of IDA in complex febrile seizures (CFS) and simple febrile seizures (SFS) and there is no report on whether IDA is a risk factor for recurrence. The aim of this study was to investigate the role of IDA in SFS and CFS and to examine the effect of IDA on recurrence.
Patients (n=166) who had been diagnosed with FS were enrolled in our study. Subjects were divided into the following groups for analysis: the SFS and CFS groups, recurrence and non-recurrence groups. The onset age was compared in each group of patients and laboratory test results based on IDA were compared.
Between the SFS and the CFS groups, there was no significant difference in laboratory test results based on IDA. There was a significant difference in onset age between the two groups and the onset age tended to be lower in the CFS group (24.00 vs. 16.49 months) (P=0.004). Comparing recurrence and non-recurrence groups, the mean corpuscular volume was significantly different (P=0.043) with the recurrence group having a lower mean corpuscular volume level (78.92 vs. 77.48). The onset age in the recurrence group was lower (26.02 vs. 19.68 months).
This study suggests that onset age could be a risk factor for CFS, and IDA may not contribute to elevating the risk of CFS. However, IDA may play an important role in the recurrence of FS.
Key Words: Febrile seizure, Recurrence, Iron deficiency anemia
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