J Korean Child Neurol Soc Search

CLOSE


Journal of the Korean Child Neurology Society 2002;10(1):20-28.
Published online May 30, 2002.
Age-Related Changes of MHC Class II-immunoreactive Dendritic Cells in Rat Brain.
Pil Soon Yang, Kyu Geun Hwang, Ki Soo Yoo
1Department of Pediatrics, Dong-A University, College of Medicine, Pusan, Korea. gkhyang@daunet.donga.ac.kr
2Department of Anatomy, Dong-A University, College of Medicine, Pusan, Korea.
Abstract
PURPOSE
Dendritic cells are antigen presenting cells(APC) that express class II major histocompatibility complex gene products on their surface. Recently, it was proved that dendritic cells activate antitumor immunity for intracranial germ cell tumor. The aim of the present study is to investigate the age-related changes of MHC class II-immunoreactive dendritic cells in the rat brain. METHODS: Male rats(Sprague-Dawley) were sacrificed at 1 month, 12 months and 24 months after birth. Brains were removed and sliced in rat brain matrix. Brain slices were cryosectioned coronally at interaural 5.70-6.70 mm. Brain tissue sections were immunohistochemically reacted with monoclonal MHC class II antibody. RESULTS: MHC class II-immunoreactive dendritic cells were observed in choroid plexuses and white matter(corpus callosum, cerebral peduncle and external capsule). The number of MHC class II-immunoreactive dendritic cells was slightly increased with age. As age increases, shapes of MHC class II-immunoreactive dendritic cells became more complex and aggregated together. CONCLUSION: As age increases, MHC class II-immunoreactive dendritic cells in choroid plexuses and white matter of the brain became not only more complex in shape, but also increased in number to improve immunity.
Key Words: Dendritic cell, MHC class II molecule, Aging, Rat brain
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 293 View
  • 1 Download
Related articles in Ann Child Neurol


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
EDITORIAL POLICY
AUTHOR INFORMATION
Editorial Office
50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
Tel: +82-2-2019-3350    Fax: +82-2-2019-4881    E-mail: editor@annchildneurol.org                

Copyright © 2022 by Korean Child Neurology Society.

Developed in M2PI

Close layer
prev next