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Journal of the Korean Child Neurology Society 2002;10(1):54-62.
Published online May 30, 2002.
Ketogenic Diet for Intractable Epilepsy in Infancy and Childhood: Anti-epileptic Efficacy and Tolerability.
So Youn Lee, Deok Soo Kim, Tae Sung Ko
Department of Pediatrics, College of Medicine, Ulsan University, Seoul, Korea. tsko@www.amc.seoul.kr
The Ketogenic diet has been used since the 1920s as an alternative therapy to antiepileptic drugs in children with intractable epilepsy. This study was performed to provide information of clinical efficacy, adverse effects, tolerability and reasons for discontinuation. METHODS: This is a retrospective study concerning the change in frequency of seizures according to seizure classification, complication, tolerability and reasons for discontinuation in 25 children with intractable epilepsy who were treated with the 4:1 ketogenic diet. RESULTS: One month after diet initiation, complete cessation of seizures was observed in 5 children(20%), a greater than 50% reduction of seizures in 5 children(20%). One month after diet initiation, 72% continued the ketogenic diet. At 3 months, 44% continued the ketogenic diet. Most of those discontinued the diet because it was either ineffective or too unpalatable. Gastrointestinal side effects were observed in 10 children(40%), 8 controlled by supportive care, and 2 no longer maintaing the ketogenic diet. CONCLUSION: The ketogenic diet should be considered as an alternative therapy for children with intractable epilepsy. To maintain the ketogenic diet for a long time, family education, careful follow-up and development of various diet regimens should be considered.
Key Words: Epilepsy, Ketogenic diet, Tolerability
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